Moonlight on the Bayou

Caroline moves to Dallas with Alaric and the twins. Valerie locates an anti-magic bar in New Orleans, "St. James Infirmary" where Stefan must hide (as Rayna's sword will not be able to trace him there). At the bar, Stefan meets Klaus. He eventually finds out that Stefan is there hiding from Rayna and is furious. He asks Stefan to leave, and Stefan forgets his phone. Klaus gets to talk with Caroline, finally agreeing to protect Stefan and does so. While on the run, both Nora and Mary Louise are tranquilized and captured by men who work for "The Armory". Meanwhile, Bonnie and Damon meet Enzo at a supernatural museum-like organization named "The Armory", who are desperate to lock up Rayna. Enzo works for them as they are giving him information about his family. He wants to know Stefan's location in order to lure Rayna in. Damon adamantly keeps his brother's location a secret after getting warned about the organization's dubious past from Valerie. An equally adamant Enzo tranquilizes Damon and knocks out Bonnie (it is shown that, somehow, Enzo makes Bonnie immune to magic). Damon finds himself locked in with a comatose Tyler who will soon transition into a werewolf because it is a full moon. Bonnie takes desperate measures to save Damon from being bitten. Damon struggles with Tyler, who makes him realize that "people around him are always dying in order to save him and it must stop". Taking it to heart, Damon advises Bonnie to not open the cell as she could die. Undeterred, Bonnie manages to open the cell, only to get her skull bashed by Tyler who runs away after a fight. Damon sees that she is not healing with his blood and gets her hospitalized. As he talks to an unconscious Bonnie, he says that he is deeply hurt to have put her and Stefan's lives in danger, both of whom tried to save him. This makes him think that it would be best to take himself out of the equation as to no longer bother his loved ones, and it will all end tomorrow.

This episode begins a crossover with The Originals that concludes on "A Streetcar Named Desire".

----

Flashforward: Caroline and the twins have come to meet Klaus at the same bar that Stefan was hiding. A waitress informs her that it has been three years since Klaus has disappeared.

Plot summary from Wikipedia (CC BY-SA 4.0). Source